Guest Artist:Eric Lau, Saxophone

Kemp Recital Hall Wednesday Evening October 17, 2007 7:30p.m

Exparel Compared to Standard Bupivacaine for Postoperative Analgesia Following Lumbar Spine Fusion

Inadequate postoperative pain management following spinal surgery contributes to delayed mobilization and chronic pain. The current standard of care following spinal surgery consists of opiates and anesthetics to target multiple pain pathways. However, opiates are limited by their significant adverse effects and anesthetics are limited by their short duration of delivery. One approach that may overcome these limitations is liposomal or lipid-encapsulated drug formulations, which have been shown to extend the duration of drug delivery to target tissues. In this study, we will compare adjunctive opioid consumption in a randomized controlled trial of patients undergoing elective posterior lumbar spinal surgery that receive liposomal and conventional anesthetic versus conventional anesthetic. We hypothesize that liposomal anesthetic will improve pain management by reducing the total adjunctive opioid consumption required. This study will address a key limitation of conventional anesthetics and may provide evidence for the utility of liposomal anesthetic in postoperative pain management

Use of Graphic Images and Text Characters in Internet Banners as an Effective Marketing Tool

Participants were presented with a list of Internet banners and asked to perform a series of matching tasks to test the effectiveness of using graphic images as compared with verbal characters in web-site banners for e-marketing purposes. Participants studied ten different web pages. The web banners consisted of image or characters that had some degree of linkage to the corresponding web contents. Results show that: (a) participants have a greater ability to match web contents if banners are relevant to the web page contents; (b) contextual cues can be enriched by the context of the images used in the web banners; (c) frequent web surfers are less likely to recall web banners than normal web users. These findings are discussed in light of research on the effect of “picture superiority” and “semantic coding” on memory of pictures and words. This study concluded that the selection of graphic elements in web banners is important to an effective e-marketing strategy

Analysis of post-transplant lymphoproliferative disorder (PTLD) outcomes with Epstein-Barr virus (EBV) assessments-a single tertiary referral center experience and review of literature

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoid or plasmacytic proliferations ranging from polyclonal reactive proliferations to overt lymphomas that develop as consequence of immunosuppression in recipients of solid organ transplantation (SOT) or allogeneic bone marrow/hematopoietic stem cell transplantation. Immunosuppression and Epstein-Barr virus (EBV) infection are known risk factors for PTLD. Patients with documented histopathologic diagnosis of primary PTLD at our institution between January 2000 and October 2019 were studied. Sixty-six patients with PTLD following SOT were followed for a median of 9.0 years. The overall median time from transplant to PTLD diagnosis was 5.5 years, with infant transplants showing the longest time to diagnosis at 12.0 years, compared to pediatric and adolescent transplants at 4.0 years and adult transplants at 4.5 years. The median overall survival (OS) was 19.0 years. In the monomorphic diffuse large B-cell (M-DLBCL-PTLD) subtype, median OS was 10.7 years, while median OS for polymorphic subtype was not yet reached. There was no significant difference in OS in patients with M-DLBCL-PTLD stratified by quantitative EBV viral load over and under 100,000 copies/mL at time of diagnosis, although there was a trend towards worse prognosis in those with higher copies

Shock Wave-Induced Damage of a Protein by Void Collapse

In this study, we report on a series of molecular dynamics simulations that were used to examine the effects of shock waves on a membrane-bound ion channel. A planar shock wave was found to compress the ion channel upon impact, but the protein geometry resembles the crystal structure as soon as the solvent density begins to dissipate. When a void was placed in close proximity to the membrane, the shock wave proved to be more destructive to the protein due to formation of a nanojet that results from the asymmetric collapse of the void. The nanojet was able to cause significant structural changes to the protein even at low piston velocities that are not able to directly cause poration of the membrane